ASCORBIC ACID SYNTHESIS IN NORMAL AND DRUG-TREATED RATS, STUDIED WITH l-ASCORBIC-1-C14 ACID
نویسندگان
چکیده
منابع مشابه
Ascorbic acid synthesis in normal and drug-treated rats, studied with L-ascorbic-1-C14 acid.
It is known that, of all animal species studied, only man, other Primates, and the guinea pig are unable to synthesize ascorbic acid. Results obtained in rats, with radioactive glucose, indicate that ascorbic acid is synthesized by a fairly direct route from glucose (l-3), but no information has been available concerning the rate of synthesis and metabolism of ascorbic acid. Such information wo...
متن کاملSynthesis of C14-Labeled L-Sorbose and L-Ascorbic Acid
A m ethod is prese nted for preparing C'4-l abeled L-ascorbi c acid (vi tamin C) from labeled banum D-gluconate or D-glucose. The process is adapted from t he commercial synthesis of vi tamin C t hrough sorbitol, L-sorbose and potassium di-O-isopropylidene-2kelo-L-guloll.ate. In .th e cyanohydrin . synt hesis of labeled D-glucose, barium D-gluconate is used as an lI1term ed~at~ . Fo: prepanng l...
متن کاملMetabolism of L-ascorbic acid-1-C14 in man.
n-Ascorbic acid labeled with Cl4 has been utilized in studying the metabolism of this vitamin in rats (1, 2) and guinea pigs (3, 4). In both species there is considerable conversion of carboxyl-labeled n-ascorbic acid to CO2 and significant urinary excretion of labeled oxalate. The important nutritional role of n-ascorbic acid made it desirable to study the metabolism of the labeled vitamin in ...
متن کاملThe metabolism of ascorbic acid-1-C14 and oxalic acid-C14 in the rat.
It is known that oxalic acid is a product of ascorbic acid metabolism in the guinea pig (1) and rat (2), and is formed in man from unidentified precursors (3). Oxalates are also of interest because of their occasional toxicity and unexplained deposition. Ascorbic, dehydroascorbic, and 2,3diketogulonic acids are known to give rise to oxalic and threonic acids in approximately quantitative yields...
متن کاملIdentification of L-ascorbic acid in the urine of normal and chloretone-treated rats.
About 10 years ago, King, Longenecker, and their associates made the interesting observation that the urine of rats subsisting on a milk diet which was supplemented with a non-saponifiable fraction from oat oil, grass leaf oil, or alfalfa leaf oil (2) or with certain terpenes (3) or hypnotics, particularly chloretone (4), contained considerable quantities of a reducing substance. This reducing ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1954
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)65685-6